Other agencies & respected journals recognised the seriousness of nexium-plavix interaction and alerted the medical community. So when when FDA finally issued a warning, then there is no reason not to pay heed if you are still doing this combination.
Feb 2009: The Canadian Medical Association Journal:
http://www.prescriber.org.uk/2009/02/ppi-interaction-with-clopidogrel/
Mar 2009: JAMA press release:
http://jama.ama-assn.org/cgi/content/abstract/301/9/937
May 2009: European Medicines Agency (EMEA) press release:
http://www.ema.europa.eu/humandocs/PDFs/EPAR/Plavix/32895609en.pdf
Nov 2009: FDA warning in :
http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm190784.htm
The only safer alternative recommended is pantoprazole as it does not affect CYP4502C19 which is necessary to activate Plavix.
http://www.theheart.org/article/1003033.do
Sunday, January 17, 2010
Sunday, January 3, 2010
Are you taking a Placebo?
For those heart patients who are taking Plavix blood thinner to help their heart work easier but are also taking acid-reducing PPI Nexium for their GERD (gastric reflux)or any of these like Tagamet, Prozac, then they might as well be taking a Placebo.
The drugs may make the anti-clotting drug Plavix dangerously less effective which means 3.58 times greater risk for major adverse cardiovascular events such as death, heart attack, and stroke. This risk was published in December 22, 2008.
http://content.nejm.org/cgi/content/abstract/NEJMoa0808227v1..
This risk was again brought to media attention in March 2009.
http://www.medicinenet.com/script/main/art.asp?articlekey=98231
The FDA eventually issued this warning on Nov 17.
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm190848
The drugs may make the anti-clotting drug Plavix dangerously less effective which means 3.58 times greater risk for major adverse cardiovascular events such as death, heart attack, and stroke. This risk was published in December 22, 2008.
http://content.nejm.org/cgi/content/abstract/NEJMoa0808227v1..
This risk was again brought to media attention in March 2009.
http://www.medicinenet.com/script/main/art.asp?articlekey=98231
The FDA eventually issued this warning on Nov 17.
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm190848
Friday, November 6, 2009
Only you can take care of your heart.
You haven't been feeling too well lately. You are tired, breathless & you blame it on the heavy workload, the environment and everything else that cause your stress-o-meter to swing up.
Then you feel a pain in your chest, and maybe nausea and you feel pain in your arms, neck or jaw. You are having a heart attack.
Getting emergency medical treatment fast is so important. How long you delay will determine whether you live and how much heart damage you sustain.
However, not all heart attacks are so dramatic like those we see on TV. They are usually quite insidious but when you are aware of the symptoms, you can prevent permanent or serious damage to your life.
Then you feel a pain in your chest, and maybe nausea and you feel pain in your arms, neck or jaw. You are having a heart attack.
Getting emergency medical treatment fast is so important. How long you delay will determine whether you live and how much heart damage you sustain.
However, not all heart attacks are so dramatic like those we see on TV. They are usually quite insidious but when you are aware of the symptoms, you can prevent permanent or serious damage to your life.
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